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Most clinicians recommend pausing use

Animal experiments and clinical verification Animal experiments serve as a cornerstone in the study of antidepressant Chinese medicines

However, folic acid cannot fix the damage to the nervous system caused by low B12, which can lead to permanent nerve damage if the B12 deficiency isn't found and treated

Because of these factors, laws worldwide define which drugs are prescription only. For example, in the United States the Food and Drug Administration (FDA) designates drugs as Rx only (meaning prescription required) if they are not safe for self-medication